Carbon tetrabromide → HCID 79997855, compound

HRID 1477621Notes

Reaction equation

HRID 1477621 reaction equation
[Br:1][C:2]1[S:6][C:5]([CH2:7]O)=[CH:4][C:3]=1[CH3:9].C(Br)(Br)(Br)[Br:11].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[Br:1][C:2]1[S:6][C:5]([CH2:7][Br:11])=[CH:4][C:3]=1[CH3:9]

Participants

5

Reactant 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 799976971432062-10-6

Product 1

HCID 79997855HCID 79997855, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a tetrahydrofuran solution (1.0 mL) of (5-bromo-4-methylthiophen-2-yl)methanol (33.7 mg, 0.163 mmol) synthesized in Reference Synthesis Example 100, carbon tetrabromide (59.4 mg, 0.179 mmol) and triphenylphosphine (47.0 mg, 0.179 mmol) were added and the resultant solution was stirred at room temperature for 20 hours. After completion of the reaction, the reaction solution was filtered and the obtained filtrate was concentrated under reduced pressure to obtain the title compound as a crude product.

Workup

  1. additionwere added
  2. customAfter completion of the reaction
  3. filtrationthe reaction solution was filtered
  4. concentrationthe obtained filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-b1fc181e846e4139b63826a7187dd7d0
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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