Sodium Bicarbonate → HCID 67870438, compound

HRID 1477663Notes

Reaction equation

HRID 1477663 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH:8]=2)[S:5][CH:6]=1.C(=O)(O)[O-].[Na+]>>[CH3:1][C:2]1[CH:3]=[C:4]([C:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH:8]=2)[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 117925592HCID 117925592, compound

Product 1

HCID 67870438HCID 67870438, compound

Procedure

To a crude product synthesized by using tert-butyl 4-(4-methylthiophen-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (10.0 mg, 0.358 mmol) in a similar manner to Reference Synthesis Example 26, saturated sodium bicarbonate aqueous solution was added and extraction from the resultant mixture with ethyl acetate was performed. The organic layer was washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain a crude product of the title compound.

Workup

  1. additionwas added
  2. extractionextraction from the resultant mixture with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b1630e1d163b44d9891f23324efb7fac
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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