Benzoyl isothiocyanate → HCID 86688406, compound

HRID 1477763Notes

Reaction equation

HRID 1477763 reaction equation
[CH3:1][N:2]1[C:10]([NH2:11])=[C:9]2[C:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)=[N:3]1.[C:12]([N:20]=[C:21]=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(C)=O>[CH3:1][N:2]1[C:10]([NH:11][C:21]([NH:20][C:12](=[O:19])[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[S:22])=[C:9]2[C:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)=[N:3]1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 529036082-Methyl-4,5,6,7-tetrahydro-2H-indazol-3-amine

Product 1

HCID 86688406HCID 86688406, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of compound 124 (5.44 g, 33.1 mmol) in 40 mL of acetone at 0° C. was added dropwise benzoyl isothiocynate (5.4 g, 33.1 mmol). The reaction mixture was gradually warmed up and stirred in an oil bath of 60° C. until TLC indicated there was no starting material remained.

Workup

  1. temperatureThe reaction mixture was gradually warmed up and

Sources & evidence

ORD record
ord-0ed7ae02d4164ea190e614c3bb22e5df
Source dataset
uspto-grants-2016_08
Patent number
US09403815B2

Reaction notes

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