HCID 57523965, compound → HCID 57524056, compound

HRID 1477876Notes

Reaction equation

HRID 1477876 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:15]2[C:23]3[C:18](=[C:19]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[CH:20]=[CH:21][CH:22]=3)[CH:17]=[N:16]2)([CH2:13][CH3:14])/[CH:9]=[CH:10]/[C:11]#[N:12])=[CH:4][CH:3]=1>CC(=O)OCC.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:15]2[C:23]3[C:18](=[C:19]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[CH:20]=[CH:21][CH:22]=3)[CH:17]=[N:16]2)([CH2:13][CH3:14])[CH2:9][CH2:10][C:11]#[N:12])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 57523965HCID 57523965, compound

Product 1

HCID 57524056HCID 57524056, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of (E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indazol-4-yl)methanesulfonamide (60 mg) and 10% Pd/C in EA (4 mL) was stirred at room temperature under H2 atmosphere for 16 h. The mixture was filtered and evaporated to give the title compound as a pale yellow solid. LC/MS m/z=417.2[M+H]+.

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-decdd1a6be33446b8e2d167e9bea02c0
Source dataset
uspto-grants-2016_08
Patent number
US09403807B2

Reaction notes

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