反应详情

To a solution of the product from Step C above (0.083 g, 0.16 mmol) and anisole (0.068 g, 0.63 mmol) in DCM (1.0 mL) was added TFA (0.18 g, 1.58 mmol). After stirred overnight at RT, the reaction mixture was concentrated to dryness under reduced pressure. The resulting residue was re-dissolved in a mixture of acetonitrile and water followed by addition of 1 N HCl aqueous solution (0.16 mL). The solution was dried in a lyophilized to give crude title compound. LC/MS m/z=426.1[M+H]+.

1. concentrationthe reaction mixture was concentrated to dryness under reduced pressure
2. dissolutionThe resulting residue was re-dissolved in a mixture of acetonitrile and water
3. additionfollowed by addition of 1 N HCl aqueous solution (0.16 mL)
4. customThe solution was dried in