Sodium Acetate → HCID 123447799, compound

HRID 1478552Notes

Reaction equation

HRID 1478552 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH:11]=[C:10]([C:12]3[S:13][C:14]4[CH2:20][CH2:19][CH2:18][C:17](=O)[C:15]=4[N:16]=3)[CH:9]=[N:8]2)[CH:2]=1.Cl.[CH3:23][O:24][NH2:25].C([O-])(=O)C.[Na+]>C1COCC1>[CH3:23][O:24][N:25]=[C:17]1[C:15]2[N:16]=[C:12]([C:10]3[CH:9]=[N:8][N:7]([C:3]4[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=4)[CH:11]=3)[S:13][C:14]=2[CH2:20][CH2:19][CH2:18]1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 90044011HCID 90044011, compound

Product 1

HCID 123447799HCID 123447799, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-[1-(3-pyridyl)pyrazol-4-yl]-6,7-dihydro-5H-1,3-benzothiazol-4-one (0.40 mmol, 0.119 g) was suspended in 4 ml THF, and O-methylhydroxylamine hydrochloride (0.44 mmol, 0.0367 g) followed by sodium acetate (0.80 mmol, 0.0656 g) were added. The reaction mixture was heated at reflux. After evaporation of the solvent, the residue was submitted to chromatography (Combiflash) to yield the title compound as a yellow solid.

Workup

  1. additionwere added
  2. temperatureThe reaction mixture was heated
  3. temperatureat reflux
  4. customAfter evaporation of the solvent

Sources & evidence

ORD record
ord-5ae0a231072845de9426daf040fa948e
Source dataset
uspto-grants-2016_08
Patent number
US09403845B2

Reaction notes

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