反应详情

温度

70 °C

tert-butyl 3-((tosyloxy)methyl)piperidine-1-carboxylate (8.85 g, 24 mmol) was dissolved in DMF (100 ml), and then NaN3 (6.24 g, 96 mmol) and NaI (0.36 g, 2.40 mmol) were added, followed by stirring at 70° C. for hours. After the completion of the reaction, the reaction mixture was extracted with H2O, EA, and brine, followed by drying (Na2SO4), filtration, and concentration under reduced pressure, and the residue was purified by column chromatography (EA:Hex=1:10), to give tert-butyl 3-(azidomethyl)piperidine-1-carboxylate (5.38 g, 92%).

1. customAfter the completion of the reaction
2. extractionthe reaction mixture was extracted with H2O, EA, and brine
3. customby drying
4. filtration(Na2SO4), filtration, and concentration under reduced pressure
5. customthe residue was purified by column chromatography (EA:Hex=1:10)