Trifluoroacetic acid → HCID 118364825, compound

HRID 1478593Notes

Reaction equation

HRID 1478593 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][CH:17]4[CH2:22][CH2:21][CH2:20][N:19](C([O-])=O)[CH2:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][CH:17]4[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131736510HCID 131736510, compound

Product 1

HCID 118364825HCID 118364825, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)piperidine-1-carboxylate (0.45 g, 0.89 mmol) was dissolved in CH2Cl2 (5 ml), and then TFA (5 ml) was added, followed by stirring at room temperature overnight. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure, and the next reaction was advanced without purification.

Workup

  1. customAfter the completion of the reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customthe next reaction
  4. customwas advanced without purification

Sources & evidence

ORD record
ord-9bea9762d6394bed83c03d1ee84365ef
Source dataset
uspto-grants-2016_08
Patent number
US09403831B2

Reaction notes

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