Hydrochloric Acid → HCID 23145973, compound

HRID 1479017Notes

Reaction equation

HRID 1479017 reaction equation
[OH-].[Na+].C[O:4][C:5](=[O:20])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH:12]=[C:13]1[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]1.Cl>CCO>[CH3:19][N:16]1[CH2:17][CH2:18][C:13](=[CH:12][C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5]([OH:20])=[O:4])[CH2:14][CH2:15]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 89650329HCID 89650329, compound

Product 1

HCID 23145973HCID 23145973, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1M NaOH (2 mL; 2 mmol; 4.9 eq.) was added to a solution 2-(1-methyl-piperidin-4-ylidenemethyl)-benzoic acid methyl ester (100 mg; 0.41 mmol; 1 eq.) in EtOH (2 mL) and the reaction mixture was stirred at room temperature for 16 hours. The pH was adjusted to 5 with 1M HCl and the solution was concentrated in vacuo to afford the title compound as a white solid which was used without further purification. HPLC (max plot) 99.1%; Rt 1.69 min.

Workup

  1. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-a9f66e95fd7a448eb61324804e56cab9
Source dataset
uspto-grants-2016_08
Patent number
US09403835B2

Reaction notes

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