Hydrochloric Acid → HCID 89650310, compound

HRID 1479027Notes

Reaction equation

HRID 1479027 reaction equation
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[OH-].[Na+].Cl>CCO>[CH3:17][N:14]1[CH2:15][CH2:16][CH:11]([CH2:10][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([OH:18])=[O:2])[CH2:12][CH2:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 89650483HCID 89650483, compound

Product 1

HCID 89650310HCID 89650310, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 2-(1-methyl-piperidin-4-ylmethyl)-benzoic acid methyl ester (97 mg; 0.39 mmol; 1 eq.) and 5M NaOH (2 mL) in EtOH (3 mL) was stirred at 60° C. for 4 hours. After cooling down, the solution was neutralised with 1M HCl and freeze dried to afford the title compound as a white solid which was used without further purification. HPLC (max plot) 99.8% Rt 1.77 min. UPLC/MS: (MS+) 248.2 ([M+H]+).

Workup

  1. temperatureAfter cooling down
  2. customdried

Sources & evidence

ORD record
ord-79472caa7bb24041b55ac054549c9d56
Source dataset
uspto-grants-2016_08
Patent number
US09403835B2

Reaction notes

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