反应详情

温度

20 °C

A mixture of methyl 4-(pentan-2-yl)benzoate (634 mg, 3.1 mmol), lithium hydroxide monohydrate (646 mg, 15.4 mmol), tetrahydrofuran (12.0 mL), methanol (4.0 mL) and water (4.0 mL) was stirred at 20° C. for 4 hours. The mixture was acidified to pH=3-4. The mixture was extracted with ethyl acetate (20 ml×3). The organic phase was dried by sodium sulfate. The mixture was filtered. The filtrate was concentrated and the residue was purified by column chromatography (silica gel, petroleum/ethyl acetate=6:1) to gave 4-(pentan-2-yl)benzoic acid (E1-c) as a white solid (487 mg, 82%). LRMS (M−H)− m/z: 192.12. found 192.

1. extractionThe mixture was extracted with ethyl acetate (20 ml×3)
2. dry with materialThe organic phase was dried by sodium sulfate
3. filtrationThe mixture was filtered
4. concentrationThe filtrate was concentrated
5. customthe residue was purified by column chromatography (silica gel, petroleum/ethyl acetate=6:1)