反应详情

To a solution of lithium hydroxide (121 mg, 2.9 mmol) in tetrahydrofuran, methanol and water (20 mL, 3:1:1, V/V) was added methyl 4-(pentan-2-yl)benzoate (170 mg, 0.58 mmol). The reaction mixture was stirred at room temperature for 1 hour. The mixture was quench with 10% hydrochloric acid aqueous, extracted with dichloromethane and menthol (20 ml, 10:1), the combine organic layer was dried by anhydrous sodium sulfate, filtered and concentrated to give product 4-(pentan-2-yl)benzoic acid as a white yield (160 mg, 99%).

1. customThe mixture was quench with 10% hydrochloric acid aqueous
2. extractionextracted with dichloromethane and menthol (20 ml, 10:1)
3. dry with materialthe combine organic layer was dried by anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated