Phenylacetic Acid → HCID 117734872, compound

HRID 1479897Notes

Reaction equation

HRID 1479897 reaction equation
[NH2:1][C@H:2]([C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1)[C:3]([OH:5])=O.[O:13]1[CH2:17][CH2:16][CH2:15][C@@H:14]1[CH2:18][NH2:19].[CH3:20][O:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH:24]=O.[C:30]1([CH2:36][C:37](O)=[O:38])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH3:20][O:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24][N:1]([C@H:2]([C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1)[C:3](=[O:5])[NH:19][CH2:18][C@H:14]1[CH2:15][CH2:16][CH2:17][O:13]1)[C:37](=[O:38])[CH2:36][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

5

Reactant 4

HCID 999Phenylacetic AcidHCID 86582-MethoxybenzaldehydeHCID 2734124(R)-(-)-TetrahydrofurfurylamineHCID 7033007HCID 7033007, compound

Product 1

HCID 117734872HCID 117734872, compound

Procedure

Alternatively, the compound was prepared following the general procedure described for intermediate C starting from commercially available (2R)-amino(4-methylphenyl)ethanoic acid and 1-[(2R)-tetrahydrofuran-2-yl]methanamine. Compound 7a was then prepared following the general procedure 3 starting from 2-methoxybenzaldehyde and phenylacetic acid. MS (ES1+) m/z: 487.33 (M+1).

Workup

  1. customAlternatively, the compound was prepared

Sources & evidence

ORD record
ord-daaecee6d9cb438aaecb7fd5a1b67ba9
Source dataset
uspto-grants-2016_08
Patent number
US09409876B2

Reaction notes

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