反应详情

Methyl benzenesulfonate (0.019 mL, 0.14 mmol) was added to a solution of 5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-N-[3-(dimethylamino)propyl]-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-2,3-dihydro-1H-imidazole-1-carboxamide (Example 9) (77 mg, 0.14 mmol) in THF (3.0 mL). The mixture was stirred for 2 hr then allowed to stand at RT for 2 days. Water (15 mL) and EtOAc (15 ml) were added with stirring. The phases were separated. The aqueous phase was washed with EtOAc (15 mL) then diluted with MeCN. The solvents were removed by lyophilisation to afford the title compound (70 mg) a white solid.

1. waitto stand at RT for 2 days
2. stirringwith stirring
3. customThe phases were separated
4. washThe aqueous phase was washed with EtOAc (15 mL)
5. additionthen diluted with MeCN
6. customThe solvents were removed by lyophilisation