Hydrochloric Acid → HCID 121393765, compound

HRID 1480033Notes

Reaction equation

HRID 1480033 reaction equation
C([O:3][C:4]1[N:5]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)[C:6]([CH3:22])=[C:7]([C:9]2[N:13]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)[N:12]=[CH:11][N:10]=2)[N:8]=1)C.Cl>CC(C)=O>[CH3:22][C:6]1[N:5]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:31])([F:32])[F:30])[CH:24]=2)[C:4](=[O:3])[NH:8][C:7]=1[C:9]1[N:13]([C:14]2[CH:15]=[CH:16][C:17]([C:18]#[N:19])=[CH:20][CH:21]=2)[N:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 121393766HCID 121393766, compound2×

Product 1

HCID 121393765HCID 121393765, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-{5-[2-Ethoxy-5-methyl-1-(3-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-[1,2,4]triazol-1-yl}-benzonitrile (Intermediate 14, 130 mg, 0.30 mmol), acetone (4 ml) and 5M HCl (3 ml) were heated together at 60° C. for 2 h and allowed to cool. The acetone was removed in vacuo and the aqueous solution basified with NaHCO3 solution.

Workup

  1. temperatureto cool
  2. customThe acetone was removed in vacuo

Sources & evidence

ORD record
ord-e2b8e2e851554283941bf08fb280ea73
Source dataset
uspto-grants-2016_08
Patent number
US09409870B2

Reaction notes

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