2-Amino-2-methyl-1-propanol → 5-Chloro-4-(3-chlorophenyl)-pyridine-2-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

HRID 1480038Notes

Reaction equation

HRID 1480038 reaction equation
[Cl:1][C:2]1[C:3]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:18][C:19]([CH3:23])([CH3:22])[CH2:20][OH:21]>>[OH:21][CH2:20][C:19]([NH:18][C:8]([C:5]1[CH:4]=[C:3]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 902037665-Chloro-4-(3-chlorophenyl)-pyridine-2-carboxylic acid

Product 1

HCID 762819985-Chloro-4-(3-chlorophenyl)-pyridine-2-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-(3-chlorophenyl)-pyridine-2-carboxylic acid and 2-amino-2-methyl-1-propanol (CAN 124-68-5) as starting materials and isolated (13 mg, 38%) as colorless oil; MS (ESI, m/z): 339.0, 341.0 (MH+).

Workup

  1. customisolated (13 mg, 38%) as colorless oil

Sources & evidence

ORD record
ord-2b59f2162a254c9aaa3ebe6ebc239d7d
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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