Tert-Butylamine → HCID 90204122, compound

HRID 1480131Notes

Reaction equation

HRID 1480131 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:19][C:20]([NH2:23])([CH3:22])[CH3:21]>>[C:20]([NH:23][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])([CH3:22])([CH3:21])[CH3:19]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 90204122HCID 90204122, compound

Procedure

The title compound was synthesized in analogy to Example 63b, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2-methylpropan-2-amine (CAN 75-64-9) as starting materials and isolated (12.5 mg, 17%) as colorless oil; MS (ESI, m/z): 317.1 (M+H+).

Workup

  1. customisolated (12.5 mg, 17%) as colorless oil

Sources & evidence

ORD record
ord-061e027c90cc4b649a7a13ed8c722fe0
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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