2-Fluoroethanol → HCID 90203478, compound

HRID 1480219Notes

Reaction equation

HRID 1480219 reaction equation
Cl[C:2]1[C:7]([CH:8]2[CH2:10][CH2:9]2)=[CH:6][N:5]=[C:4]([C:11]#[N:12])[CH:3]=1.[F:13][CH2:14][CH2:15][OH:16].[H-].[Na+]>>[CH:8]1([C:7]2[C:2]([O:16][CH2:15][CH2:14][F:13])=[CH:3][C:4]([C:11]#[N:12])=[N:5][CH:6]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 97372-FluoroethanolHCID 24758Sodium hydrideHCID 90203632HCID 90203632, compound

Product 1

HCID 90203478HCID 90203478, compound

Procedure

The title compound was synthesized in analogy to Example 123c, using 4-chloro-5-cyclopropyl-pyridine-2-carbonitrile (example 145b), 2-Fluoro-ethanol (CAN 371-62-0) as starting materials and sodium hydride as reagent. The title compound was isolated (267 mg, 68%) as a yellow solid; MS (ESI, m/z): 207.1 (M+H+).

Workup

  1. customThe title compound was synthesized in analogy to Example 123c

Sources & evidence

ORD record
ord-f1bcb73b4f7348a9b432e5e17e494b3d
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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