Hydrochloric Acid → HCID 90204175, compound

HRID 1480224Notes

Reaction equation

HRID 1480224 reaction equation
[CH:1]1([C:4]2[C:5]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:6][C:7]([C:10]([NH:12][C:13]([C:18]3[N:22]=[C:21]([CH3:23])[O:20][N:19]=3)([CH3:17])[C:14]([OH:16])=O)=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[F:30][C:31]1([F:35])[CH2:34][NH:33][CH2:32]1.Cl>>[CH:1]1([C:4]2[C:5]([O:24][CH2:25][C:26]([F:29])([F:27])[F:28])=[CH:6][C:7]([C:10]([NH:12][C:13]([C:18]3[N:22]=[C:21]([CH3:23])[O:20][N:19]=3)([CH3:17])[C:14]([N:33]3[CH2:34][C:31]([F:35])([F:30])[CH2:32]3)=[O:16])=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 27582483,3-DifluoroazetidineHCID 90203702HCID 90203702, compound

Product 1

HCID 90204175HCID 90204175, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-2-(5-methyl-1,2,4-oxadiazol-3-yl)propanoic acid (Example 147c) and 3,3-Difluoro-azetidine; hydrochloride (CAN 288315-03-7) as starting materials and isolated (18 mg, 24%); MS (ESI, m/z): 490.5 (M+H+).

Workup

  1. customisolated (18 mg, 24%)

Sources & evidence

ORD record
ord-42b25c61105647e190d24d2be8053761
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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