Hydrochloric Acid → HCID 90203683, compound

HRID 1480226Notes

Reaction equation

HRID 1480226 reaction equation
[CH:1]1([C:4]2[C:5]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:6][C:7]([C:10]([NH:12][C:13]([C:18]3[N:22]=[C:21]([CH3:23])[O:20][N:19]=3)([CH3:17])[C:14](O)=[O:15])=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:30][NH2:31].Cl>>[CH:1]1([C:4]2[C:5]([O:24][CH2:25][C:26]([F:27])([F:28])[F:29])=[CH:6][C:7]([C:10]([NH:12][C:13]([C:18]3[N:22]=[C:21]([CH3:23])[O:20][N:19]=3)([CH3:17])[C:14]([NH:31][CH3:30])=[O:15])=[O:11])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 90203702HCID 90203702, compound

Product 1

HCID 90203683HCID 90203683, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-2-(5-methyl-1,2,4-oxadiazol-3-yl)propanoic acid (Example 147c) and methylamine;hydrochloride as starting materials and isolated (5.9 mg, 16%); MS (ESI, m/z): 428.4 (M+H+).

Workup

  1. customisolated (5.9 mg, 16%)

Sources & evidence

ORD record
ord-6fdd45c840d24f27a14956c75ab64104
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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