Hydrochloric Acid → HCID 178520495, compound

HRID 1480429Notes

Reaction equation

HRID 1480429 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([NH:11][CH2:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[O:10])[O:4][N:3]=1.Cl.O1CCOCC1>CCOC(C)=O>[OH:1][C:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([NH:11][CH2:12][CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)=[O:10])[O:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178451982HCID 178451982, compound

Product 1

HCID 178520495HCID 178520495, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To tert-butyl 4-((3-(3-hydroxyisoxazol-5-yl)propanamido)methyl)piperidine-1-carboxylate (step 1) (539 mg, 1.525 mmol) in EtOAc (15 mL) was added 4N HCl in dioxane (15 ml, 60.0 mmol). The suspension was stirred at RT for 2 hrs and then concentrated under reduced pressure to give 3-(3-hydroxyisoxazol-5-yl)-N-(piperidin-4-ylmethyl)propanamide as a gum.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-62ec94df059649fd9ab7a0f564d39f80
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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