HCID 178520554, compound → HCID 178520555, compound

HRID 1480450Notes

Reaction equation

HRID 1480450 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20](=[O:29])[CH2:21][CH2:22][CH2:23][C:24]3[N:25]=[N:26][NH:27][CH:28]=3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[C:6]([Cl:8])[CH:7]=1>CCO.[Pt]>[Cl:8][C:6]1[CH:5]=[C:4]([CH2:9][CH2:10][C:11]([N:13]2[CH2:14][CH2:15][CH:16]([NH:19][C:20](=[O:29])[CH2:21][CH2:22][CH2:23][C:24]3[N:25]=[N:26][NH:27][CH:28]=3)[CH2:17][CH2:18]2)=[O:12])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

4

Reactant 1

HCID 178520554HCID 178520554, compound

Product 1

HCID 178520555HCID 178520555, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 702EthanolSolvent

Procedure

A solution of (E)-N-(1-(3-(3,5-dichlorophenyl)acryloyl)piperidin-4-yl)-4-(1H-1,2,3-triazol-4-yl)butanamide (Example 38) (70 mg, 0.160 mmol) in EtOH (6 ml) was allowed to pass through the H cube fitted with a 10% Pt/C catalytic cartridge for 3 hours. The reaction mixture was concentrated under reduced pressure to afford the title product;

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-712cebe819944f94ad98268d73b1784e
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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