Hydrochloric Acid → HCID 86722703, compound

HRID 1480488Notes

Reaction equation

HRID 1480488 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[C:23]([C:25]#[N:26])[CH:22]=[C:21]([Cl:27])[CH:20]=2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.Cl>CCOC(C)=O.O1CCOCC1>[NH2:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[C:23]([C:25]#[N:26])[CH:22]=[C:21]([Cl:27])[CH:20]=2)=[O:16])[CH2:11][CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 86722702HCID 86722702, compound

Product 1

HCID 86722703HCID 86722703, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 3-chloro-5-cyanobenzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate (1.846 g, 4.69 mmol) in EtOAc (30 ml) at RT under nitrogen was added 4M HCl in Dioxane (11.72 ml, 46.9 mmol) and the suspension stirred for 20 hours. After 3 hours a further 5 ml of 4M HCl in Dioxan was added. The solid was filtered off and dried to afford the title product as the hydrochloride salt;

Workup

  1. filtrationThe solid was filtered off
  2. customdried

Sources & evidence

ORD record
ord-cb6baac69ec24a37b7f0c2505470dec2
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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