Potassium Carbonate → HCID 89996215, compound

HRID 1480872Notes

Reaction equation

HRID 1480872 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]1[C:14]([N+:15]([O-:17])=[O:16])=[CH:13][CH:12]=[C:11]([C:18]#[C:19][Si](C)(C)C)[N:10]=1>CO>[C:18]([C:11]1[N:10]=[C:9]([O:8][CH3:7])[C:14]([N+:15]([O-:17])=[O:16])=[CH:13][CH:12]=1)#[CH:19]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 89996085HCID 89996085, compound

Product 1

HCID 89996215HCID 89996215, compoundYield 94.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Potassium carbonate (0.020 g, 0.148 mmol) was added to a solution of 2-methoxy-3-nitro-6-((trimethylsilyl)ethynyl)pyridine (Preparation 201, 0.37 g, 1.478 mmol) in MeOH (3 mL). The reaction mixture was stirred at room temperature for 1 hour. The reaction was concentrated in vacuo and diluted with EtOAc. The solution was washed with water and the organic layer was dried (Na2SO4) and concentrated in vacuo to afford the title compound as a brown solid (248 mg, 94%).

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. additiondiluted with EtOAc
  3. washThe solution was washed with water
  4. dry with materialthe organic layer was dried (Na2SO4)
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-74e7d11316e54b6da9645ea85a3ab4fd
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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