1-Methylpiperazine → 1-(3-Methoxy-4-nitrophenyl)-4-methylpiperazine

HRID 1480878Notes

Reaction equation

HRID 1480878 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:17]2[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 27792505-Fluoro-2-nitroanisole

Product 1

HCID 567772431-(3-Methoxy-4-nitrophenyl)-4-methylpiperazine

Procedure

The title compound was prepared according to the method described for Preparations 78 and 79 using 4-fluoro-2-methoxy-1-nitrobenzene and 1-methylpiperazine. The residue was purified by silica gel column chromatography eluting with 0-20% MeOH in EtOAc.

Workup

  1. customThe residue was purified by silica gel column chromatography
  2. washeluting with 0-20% MeOH in EtOAc

Sources & evidence

ORD record
ord-c4e51632a78b430a812bec9d65796c9b
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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