Tetrahydrofuran → Tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate
Reaction equation
[Al+3:21].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[Cl:1][CH2:2][C:3]1([C:16](=[O:17])[O:18][CH3:19])[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1.[H-:20].[H-:23].[H-:24].[H-:25].[Li+:22]>>[Cl:1][CH2:2][C:3]1([CH2:16][OH:17])[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1Participants
6
Sources & evidence
- ORD record
- ord-f10cf999e5cd4282a9354f3a1cce7002
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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