Hydrochloric Acid → HCID 71735460, compound

HRID 1481234Notes

Reaction equation

HRID 1481234 reaction equation
Cl.[NH2:2][CH2:3][CH:4]([C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)[C:5]([OH:7])=[O:6].C[O:16][C:17]([C:19]1[N:20]=[CH:21][C:22]2[C:27]([C:28]=1[OH:29])=[CH:26][CH:25]=[C:24]([O:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH:23]=2)=O.C[O-].[Na+].C[C:41]([N:43](C)C)=O>>[C:41]([C:21]1[C:22]2[C:27](=[CH:26][CH:25]=[C:24]([O:30][C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:23]=2)[C:28]([OH:29])=[C:19]([C:17]([NH:2][CH2:3][CH:4]([C:8]2[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=2)[C:5]([OH:7])=[O:6])=[O:16])[N:20]=1)#[N:43]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 31374DimethylacetamideHCID 10942334Sodium MethoxideHCID 22339844α-(Aminomethyl)-4-fluorobenzeneacetic acidHCID 86709142Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate

Product 1

HCID 71735460HCID 71735460, compound

Conditions

Temperature
150 °C

Procedure

A mixture of HCl salt of 3-amino-2-(4-fluoro-phenyl)-propionic acid (82 mg), 4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester (40 mg) and NaOMe (41 mg) in DMA (1 mL) was heated in an oil bath (150° C.) for 1 h. The reaction mixture was then partitioned between EtOAc and diluted HCl solution, EtOAc phase was separated and washed with water, diluted NaCl solution and dried over anhydrous sodium sulfate solution, filtered, concentrated and silica gel column column-purified to give desired product (19 mg). LC-MS ESI+: 472 (M+1)+.

Workup

  1. customThe reaction mixture was then partitioned between EtOAc and diluted HCl solution, EtOAc phase
  2. customwas separated
  3. washwashed with water, diluted NaCl solution
  4. dry with materialdried over anhydrous sodium sulfate solution
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customsilica gel column column-purified

Sources & evidence

ORD record
ord-c679699359c54561a966d086d75d9e31
Source dataset
uspto-grants-2016_08
Patent number
US09409892B2

Reaction notes

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