反应详情

To a suspension of furo[2,3-b]pyridine-3-carboxylic acid (53 mmol) in 85 mL DCM were added EDC.HCl (58 mmol), DMAP (16 mmol) and 4.3 mL MeOH. The beige suspension was stirred at RT for 2 h. The reaction mixture was diluted with 50 mL DCM and quenched with sat. aq. NaHCO3 solution. The organic phase was washed 3 times with sat. aq. NH4Cl solution and once with brine. The organic layer was dried over MgSO4 and concentrated in vacuo to obtain the desired compound as grey solid.

1. customquenched with sat. aq. NaHCO3 solution
2. washThe organic phase was washed 3 times with sat. aq. NH4Cl solution
3. dry with materialThe organic layer was dried over MgSO4
4. concentrationconcentrated in vacuo