Hydroxyamine hydrochloride → HCID 131736104, compound

HRID 1481335Notes

Reaction equation

HRID 1481335 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH:4]=O.CC([O-])=O.[Na+].Cl.[NH2:19][OH:20]>CN(C=O)C>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH:4]=[N:19][OH:20]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 128028802,4-Dichloro-6-methoxybenzaldehyde

Product 1

HCID 131736104HCID 131736104, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2,4-dichloro-6-methoxybenzaldehyde (2.39 mmol) in 5 mL DMF was cooled to 0° C. and NaOAc (2.63 mmol) followed by hydroxylamine HCl (2.63 mmol) were added. The ice bath was removed and the reaction mixture was stirred at RT for 10 min. The mixture was diluted with EtOAc and washed once with water and brine. The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired compound as white solid.

Workup

  1. additionwere added
  2. customThe ice bath was removed
  3. additionThe mixture was diluted with EtOAc
  4. washwashed once with water and brine
  5. dry with materialThe combined organic layers were dried over MgSO4
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2c776f2c33214b77837ef6bb875b0c79
Source dataset
uspto-grants-2016_08
Patent number
US09409917B2

Reaction notes

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