Hydrochloric Acid → HCID 178494022, compound

HRID 1481591Notes

Reaction equation

HRID 1481591 reaction equation
[C:1]([C:5]1[C:6]([Cl:29])=[C:7]([C:11]2[NH:28][C:14]3[C:15]([O:26][CH3:27])=[N:16][C:17]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[Cl:25])=[CH:18][C:13]=3[N:12]=2)[N:8]([CH3:10])[N:9]=1)([CH3:4])([CH3:3])[CH3:2].Cl>CC(O)C.CCOCC>[ClH:25].[C:1]([C:5]1[C:6]([Cl:29])=[C:7]([C:11]2[NH:28][C:14]3[C:15]([O:26][CH3:27])=[N:16][C:17]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[Cl:25])=[CH:18][C:13]=3[N:12]=2)[N:8]([CH3:10])[N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178494021HCID 178494021, compound

Product 1

HCID 178494022HCID 178494022, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolvent

Procedure

2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-chloro-phenyl)-4-methoxy-3H-imidazo[4,5-c]pyridine hydrochloride was prepared from 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-chloro-phenyl)-4-methoxy-3H-imidazo[4,5-c]pyridine prepared as described in Example 25) according to the procedure described in Example 2, STEP C substituting 6M HCl in IPA with 2M HCl in Et2O. 1H-NMR (CD3OD) δ: 7.69-7.65 (m, 1H), 7.53-7.60 (m, 2H), 7.42-7.49 (m, 2H), 4.40 (s, 3H), 4.10 (s, 3H), 1.47 (s, 9H). Mass Spectrum (LCMS, ESI pos.) Calculated for C21H21N5OCl2: 430.1 (M+H). Measured: 430.2.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-cf6ac086b333481c9382754e2f69d245
Source dataset
uspto-grants-2016_08
Patent number
US09409915B2

Reaction notes

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