HRID1481795
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
The product from Example 412, Step 3 (130 mg, 0.18 mmol) was dissolved in DMF (1 mL). Sodium hydride (60% dispersion in mineral oil, 15 mg, 0.36 mmol) was added to the mixture. After 10 min of vigorous stirring at room temperature, iodomethane (35 μL, 0.54 mmol) was added to the mixture. The mixture was stirred an additional 10 min at room temperature, and then was quenched with the addition of aqueous saturated NH4Cl solution (5 mL). The mixture was extracted with CH2Cl2 (5 mL). The organic extracts were concentrated. The residue was 97% pure by UPLC analysis and used without further purification.
WORKUP
后处理
- stirringThe mixture was stirred an additional 10 min at room temperature
- customwas quenched with the addition of aqueous saturated NH4Cl solution (5 mL)
- extractionThe mixture was extracted with CH2Cl2 (5 mL)
- concentrationThe organic extracts were concentrated
- customused without further purification