Diisopropylcarbodiimide → Thymidine

HRID 1482151Notes

Reaction equation

HRID 1482151 reaction equation
COC1C=CC(C([O:22][CH2:23][C@H:24]2[O:28][C@@H:27]([N:29]3[CH:37]=[C:35]([CH3:36])[C:33](=[O:34])[NH:32][C:30]3=[O:31])[CH2:26][C@@H:25]2[OH:38])(C2C=CC=CC=2)C2C=CC(OC)=CC=2)=CC=1.C(N=C=NC(C)C)(C)C>N1C=CC=CC=1>[C@@H:27]1([N:29]2[CH:37]=[C:35]([CH3:36])[C:33](=[O:34])[NH:32][C:30]2=[O:31])[O:28][C@H:24]([CH2:23][OH:22])[C@@H:25]([OH:38])[CH2:26]1

Participants

4

Reactant 2

HCID 12734DiisopropylcarbodiimideHCID 1624195'-O-(4,4'-Dimethoxytrityl)thymidine

Product 1

HCID 5789Thymidine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a nitrogen-replaced glove box, 5′-O-(4,4′-dimethoxytrityl)thymidine and N,N′-diisoproyl carbodiimide were dissolved in dehydrated pyridine with a concentration of 0.1 mol/L and 0.2 mol/L, respectively.

Sources & evidence

ORD record
ord-fb0d3f7858b44c3f81400cbd6481c089
Source dataset
uspto-grants-2016_08
Patent number
US09410951B2

Reaction notes

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