Hydrochloric Acid → HCID 86691493, compound

In a 250 mL 3-necked round-bottomed flask equipped with a mechanical stirrer, and a liquid addition device were placed 10 g (0.073 mol) of tyrosol, 22 ml (0.277 mol) of pyridine, 60 mL of DCM and stirred for 15 min to get a clear solution. Triphosgene (7.0 g, 0.071 mol of phosgene) was dissolved in 25 mL of DCM and the solution was introduced into the reaction flask over 2-3 hours. After the addition was complete, the 100 mL of 0.2 M aqueous HCl was added to the reaction mixture and stirred for 5 min. After allowing the layers to separate, the top aqueous layer was removed and discarded. The washing was repeated with three additional 100 portions of 0.2 M aqueous HCl. The reaction mixture was then dried over anhydrous magnesium sulfate and then precipitated with 100 mL of hexane. The resulting viscous oil was stirred with 200 mL of fresh hexane until the product solidified into a white solid. The product was transferred to a glass dish dried in a vacuum oven at 60° C. The polymer had a HPSEC polystyrene equivalent Mw of 7500 da and Mn of 5700 da (THF as mobile phase) and glass transition temperature (Tg) of 48° C. A number of oligomers and polymers ranging in Mw from 750 da to 40,000 da were prepared using this method.

1. customIn a 250 mL 3-necked round-bottomed flask equipped with a mechanical stirrer
2. additiona liquid addition device
3. customto get a clear solution
4. additionthe solution was introduced into the reaction flask over 2-3 hours
5. additionAfter the addition
6. stirringstirred for 5 min
7. customto separate
8. customthe top aqueous layer was removed
9. dry with materialThe reaction mixture was then dried over anhydrous magnesium sulfate
10. customprecipitated with 100 mL of hexane
11. stirringThe resulting viscous oil was stirred with 200 mL of fresh hexane until the product
12. customdried in a vacuum oven at 60° C
13. customa HPSEC polystyrene equivalent Mw of 7500 da and Mn of 5700 da (THF as mobile phase) and glass transition temperature (Tg) of 48° C
14. customwere prepared

ORD record

ord-d90d58c583644bc192823212bb41aa55

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09416090B2