Triethylamine → HCID 5189360, compound

HRID 1482901Notes

Reaction equation

HRID 1482901 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=O)=[CH:3][CH:2]=1.Cl.[C:10]1([NH:16][NH2:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C>C(O)C>[C:10]1([NH:16][N:17]=[CH:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 133894-PyridinecarboxaldehydeHCID 60962Phenylhydrazine hydrochloride

Product 1

HCID 5189360HCID 5189360, compoundYield 96.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Pyridinecarboxaldehyde (1.75 g, 16 mmol), phenylhydrazine hydrochloride (2.26 mL, 16 mmol) and triethylamine (1.65 g, 16 mmol) were dissolved in ethanol (50 mL) and heated for 1 h. The reaction mixture was cooled to room temperature. The resulting precipitates were collected and washed with petroleum ether to afford 3.04 g (94%) of 1 as a solid.

Workup

  1. temperatureheated for 1 h
  2. customThe resulting precipitates
  3. customwere collected
  4. washwashed with petroleum ether

Sources & evidence

ORD record
ord-7a5fa0858e09478198070e233267c820
Source dataset
uspto-grants-2016_08
Patent number
US09416123B2

Reaction notes

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