Triethylamine → HCID 136341389, compound

HRID 1483019Notes

Reaction equation

HRID 1483019 reaction equation
Cl.[F:2][C:3]([F:7])([F:6])[CH2:4][NH2:5].Cl.[NH:9]1[CH:13]=[CH:12][C:11](C=O)=[N:10]1.[CH2:16](N(CC)CC)C>C(#N)C>[NH:9]1[CH:13]=[C:12]([CH:16]=[N:5][CH2:4][C:3]([F:7])([F:6])[F:2])[CH:11]=[N:10]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 97722,2,2-Trifluoroethylamine hydrochlorideHCID 178479679HCID 178479679, compound

Product 1

HCID 136341389HCID 136341389, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 2,2,2-Trifluoroethylamine hydrochloride (Sigma-Aldrich) (15.2 g, 113.2 mmol) in acetonitrile (36 mL) was added 3-pyrazole carboxaldehyde hydrochloride (which could be prepared as described in Traydakov, et. al., Synthetic Communications, 2011, 41, 2430-2434) (10 g, 75.75 mmol) followed by triethylamine (31.5 ml, 226.4 mmol) at 0° C.

Sources & evidence

ORD record
ord-c5792f886f1e45c79d3b68f7db9884cf
Source dataset
uspto-grants-2016_08
Patent number
US09416124B2

Reaction notes

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