HCID 90134933, compound → HCID 69288665, compound

HRID 1483038Notes

Reaction equation

HRID 1483038 reaction equation
[N:1]([CH2:4][CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:15])[NH:6]1)=[N+]=[N-]>CCOC(C)=O.[Pd]>[NH2:1][CH2:4][CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:15])[NH:6]1

Participants

4

Reactant 1

HCID 90134933HCID 90134933, compound

Product 1

HCID 69288665HCID 69288665, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Dissolve 3-(azidomethyl)-3,4-dihydro-2H-isoquinolin-1-one (1.8 g, 8.9 mmol) in EtOAc (15 mL). Under a nitrogen atmosphere add 10% Pd/C (0.2 g) then stir overnight under a hydrogen atmosphere. Filter reaction mixture through Celite® and wash the Celite® with EtOAc. MS (m/z): 177 (M+1).

Workup

  1. filtrationFilter
  2. customreaction mixture through Celite®
  3. washwash the Celite® with EtOAc

Sources & evidence

ORD record
ord-993a92fe52f4474ab7dbf242ac845114
Source dataset
uspto-grants-2016_08
Patent number
US09416138B2

Reaction notes

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