Benzyl Chloride → HCID 117704565, compound

HRID 1483152Notes

Reaction equation

HRID 1483152 reaction equation
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15].Cl.[H-].[Na+].[CH2:25](Cl)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>CN(C)C=O>[CH2:25]([O:21][C:10]1[C:11]2[O:12][C@H:13]3[C:14](=[O:15])[CH2:16][CH2:17][C@@H:18]4[C@@:5]53[CH2:4][CH2:3][N:2]([CH3:1])[C@@H:19]4[CH2:20][C:7]([C:6]=25)=[CH:8][CH:9]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 3

HCID 7503Benzyl Chloride2×HCID 24758Sodium hydrideHCID 5462347Hydromorphone Hydrochloride

Product 1

HCID 117704565HCID 117704565, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To Hydromorphone HCl (50.0 g, 155.3 mmol) in dimethylformamide (500 mL) was added sodium hydride (14.30 g, 357.4 mmol) portionwise with cooling. The addition was conducted over 25 minutes. The reaction was stirred at room temperature for 1.5 hours before the addition of benzyl chloride (17.88 mL, 357.4 mmol) over 10 minutes with cooling. The reaction was allowed to warm to room temperature and stirred for 40 hours. The reaction was incomplete so additional benzyl chloride (1.79 mL, 15.5 mmol) was added. After 4 hours, the reaction was quenched with water (60 mL), acidified with aqueous HCl (2M, 800 mL) and washed with ethyl acetate/diethyl ether (3:1) (2×800 mL). The aqueous phase was basified with aqueous NaOH (2M, 800 mL) and extracted with ethyl acetate (2×1 L). The organic phases were combined, washed with water/brine (1:1) (2×800 mL) and dried over MgSO4 before concentration under reduced pressure. The residue was taken up in ethyl acetate and washed with water/brine (2×500 mL), dried over MgSO4 before concentration under reduced pressure to give (4R,4aR,7aR,12bS)-9-(benzyloxy)-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one (47.9 g, 95% pure by NMR, 82% yield); [M+H]+ 376.2. This was taken onto the next step without purification.

Workup

  1. temperaturewith cooling
  2. additionThe addition
  3. temperaturewith cooling
  4. additionwas added
  5. waitAfter 4 hours
  6. customthe reaction was quenched with water (60 mL)
  7. washwashed with ethyl acetate/diethyl ether (3:1) (2×800 mL)
  8. extractionextracted with ethyl acetate (2×1 L)
  9. washwashed with water/brine (1:1) (2×800 mL)
  10. dry with materialdried over MgSO4 before concentration under reduced pressure
  11. washwashed with water/brine (2×500 mL)
  12. dry with materialdried over MgSO4 before concentration under reduced pressure

Sources & evidence

ORD record
ord-98c5acff45ff4abc95f42d763771e612
Source dataset
uspto-grants-2016_08
Patent number
US09416137B2

Reaction notes

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