Potassium Carbonate → HCID 71601826, compound

HRID 1483171Notes

Reaction equation

HRID 1483171 reaction equation
C([O:4][CH2:5][CH:6]1[O:10][C:9](=[O:11])[N:8]([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][N:13]=2)[CH2:7]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[Br:18][C:15]1[CH:16]=[CH:17][C:12]([N:8]2[CH2:7][CH:6]([CH2:5][OH:4])[O:10][C:9]2=[O:11])=[N:13][CH:14]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 71601825HCID 71601825, compound

Product 1

HCID 71601826HCID 71601826, compoundYield 70%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Compound 24b (200 mg, 0.63 mmol) was dissolved in methanol (8 mL). Potassium carbonate (175 mg, 1.27 mmol) was added. Under the protection of argon, the mixture was allowed to react at room temperature for 5 hrs. The reaction was monitored by TLC (petroleum ether/ethyl acetate=5/1). After the reaction completed, the mixture was diluted with water, and extracted with ethyl acetate. The organic phase was combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate. Column chromatography (petroleum ether/ethyl acetate=5/1) afforded 120 mg of white solid (compound 24c), yield 70%.

Workup

  1. customto react at room temperature for 5 hrs
  2. extractionextracted with ethyl acetate
  3. washwashed with saturated sodium chloride solution
  4. dry with materialdried over anhydrous sodium sulfate

Sources & evidence

ORD record
ord-f48f22c48f53478faf18e6abc07b99fd
Source dataset
uspto-grants-2016_08
Patent number
US09416144B2

Reaction notes

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