3-Aminopyridine → [3-(2-Chloro-pyrimidin-4-yl)-benzyl]-pyridin-3-yl-amine

HRID 14838Notes

Reaction equation

HRID 14838 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH2:11][NH:16][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 100093-AminopyridineHCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

Product 1

HCID 86603282[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-pyridin-3-yl-amine

Procedure

Intermediate 1 was coupled with 3-aminopyridine following procedure B. LC-MS showed the product had the expected M+H+ of 297.

Sources & evidence

ORD record
ord-1a26662e7b0f40a1998da26103818dae
Source dataset
uspto-grants-2010_06
Patent number
US07732444B2

Reaction notes

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