Spermidine → HCID 86704359, compound

HRID 1484211Notes

Reaction equation

HRID 1484211 reaction equation
[C:1]([O:10][CH2:11][CH3:12])(=[O:9])/[CH:2]=[CH:3]\[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH2:20][CH2:21][NH2:22]>C1COCC1>[O:9]=[C:1]([CH2:2][CH:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[NH:22][CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][CH:2]([C:1]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])[O:10][CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 1102SpermidineHCID 5271566Diethyl Maleate

Product 1

HCID 86704359HCID 86704359, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

11.9 g (69 mmol) of diethyl maleate were added to a solution of 5 g (34.5 mmol) of spermidine in 5 ml of THF. The reaction mixture was stirred for 3 days at 60° C. After removing the solvent in vacuo, the product was obtained quantitatively as a yellow liquid.

Workup

  1. customAfter removing the solvent in vacuo
  2. customthe product was obtained quantitatively as a yellow liquid

Sources & evidence

ORD record
ord-a2973cd677db45f79d2518b4041bf0e7
Source dataset
uspto-grants-2016_08
Patent number
US09421298B2

Reaction notes

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