HCID 89588561, compound → HCID 89588814, compound

HRID 1484469Notes

Reaction equation

HRID 1484469 reaction equation
[CH2:1]([O:8][C:9]1[C:15]2[CH:16]=[C:17]([F:20])[CH:18]=[CH:19][C:14]=2[O:13][CH:12]=[C:11]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(C)C>[CH2:1]([O:8][C:9]1[C:15]2[C:14](=[CH:19][CH:18]=[C:17]([F:20])[CH:16]=2)[C:12]([OH:13])=[C:11]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 89588561HCID 89588561, compound

Product 1

HCID 89588814HCID 89588814, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
140 °C

Procedure

5-Benzyloxy-3-(4-bromo-phenyl)-7-fluoro-benzo[f][1,4]oxazepine (830 mg, 1.96 mmol) was dissolved in isopropanol, degassed under reduced pressure and purged with argon. The reaction mixture was heated at 140° C. under microwave irradiation for 1 h. The solvent was then evaporated to dryness to afford the title compound as a solid, which was used without any further purification (750 mg, 90% yield).

Workup

  1. customdegassed under reduced pressure
  2. custompurged with argon
  3. customThe solvent was then evaporated to dryness

Sources & evidence

ORD record
ord-5276394176e64a4887cf04b0fc65086e
Source dataset
uspto-grants-2016_08
Patent number
US09422243B2

Reaction notes

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