反应详情

(2,2-difluoro-7-methyl-1,3-benzodioxol-4-yl)boronic acid (Intermediate 36, 150 mg, 1.28 mmol) was dissolved in THF (1.5 mL) and a 30% w/w aqueous solution of H2O2 (2.56 mmol) and NaOH (51 mg, 1.28 mmol) were added and the reaction mixture stirred for 2 days at room temperature. The reaction was quenched with a 2N aqueous solution of HCl and diluted with ethyl acetate. Two phases were separated and the organic layer was washed twice with brine, dried over Na2SO4 and evaporated to dryness, affording the title compound (140 mg) as yellow oil.

1. customThe reaction was quenched with a 2N aqueous solution of HCl
2. additiondiluted with ethyl acetate
3. customTwo phases were separated
4. washthe organic layer was washed twice with brine
5. dry with materialdried over Na2SO4
6. customevaporated to dryness