Nitrogen → Trifluoroacetic acid

HRID 1484716Notes

Reaction equation

HRID 1484716 reaction equation
[N:1]#N.[C:3]([OH:9])([C:5]([F:8])([F:7])[F:6])=[O:4]>C(Cl)Cl>[C:3]([OH:9])([C:5]([F:8])([F:7])[F:6])=[O:4].[C:3](#[N:1])[CH3:5].[C:3]([OH:9])([C:5]([F:8])([F:7])[F:6])=[O:4]

Participants

5

Reactant 2

HCID 947NitrogenHCID 6422Trifluoroacetic acid

Product 2

HCID 6422Trifluoroacetic acidHCID 21924481TFA acetonitrile

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To N2 (0.033 g, 0.058 mmol) in DCM (0.20 mL) was added TFA (0.067 mL, 0.86 mmol). The reaction was stirred for 1 h at room temperature and then concentrated in vacuo. The residue was Purified by reverse phase chromatography: 5% (2 column volumes), 5-100% (10 column volumes) 0.1% TFA/acetonitrile//0.1% TFA/water) to provide Example 16 as a TFA salt.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was Purified by reverse phase chromatography

Sources & evidence

ORD record
ord-8b36d1f7da75481d8bd15303d0ac89d2
Source dataset
uspto-grants-2016_08
Patent number
US09422277B2

Reaction notes

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