Water → HCID 67500537, compound

HRID 1484752Notes

Reaction equation

HRID 1484752 reaction equation
[Cl:1][C:2]1[C:6]([N:7]([CH2:15][CH2:16][OH:17])[C:8](=[O:14])[CH:9]([CH3:13])[CH2:10][S:11][CH3:12])=[CH:5][N:4]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[N:3]=1.C(N(CC)CC)C.[C:31](Cl)(=[O:33])[CH3:32].O>ClCCl.CN(C)C1C=CN=CC=1>[C:31]([O:17][CH2:16][CH2:15][N:7]([C:6]1[C:2]([Cl:1])=[N:3][N:4]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:5]=1)[C:8](=[O:14])[CH:9]([CH3:13])[CH2:10][S:11][CH3:12])(=[O:33])[CH3:32]

Participants

7

Reactant 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 67500397HCID 67500397, compound

Product 1

HCID 67500537HCID 67500537, compoundYield 26.8%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-(2-hydroxyethyl)-2-methyl-3-(methylthio)propanamide (0.045 g, 0.127 mmol) in dichloromethane (1.27 ml) was added N,N-dimethylpyridin-4-amine (0.023 g, 0.190 mmol) and triethylamine (0.019 g, 0.190 mmol) followed by acetyl chloride (0.015 g, 0.190 mmol). The reaction was stirred at room temperature overnight. Water was added and the mixture was extracted with dichloromethane. The combined organic phases were concentrated and chromatographed (0-100% ethyl acetate/hexanes) to give 2-(N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-2-methyl-3-(methylthio)propanamido)ethyl acetate as a yellow oil (0.015 g, 0.034 mmol, 26.8%): IR (thin film) 1739, 1669 cm−1; 1H NMR (400 MHz, CDCl3) δ 8.97 (d, J=2.3 Hz, 1H), 8.64 (dd, J=4.7, 1.4 Hz, 1H), 8.15 (s, 1H), 8.04 (ddd, J=8.3, 2.7, 1.4 Hz, 1H), 7.47 (ddd, J=8.3, 4.8, 0.7 Hz, 1H), 4.50-3.40 (m, 4H), 2.84 (dd, J=12.7, 8.9 Hz, 1H), 2.78-2.63 (m, 1H), 2.46 (dd, J=12.7, 5.4 Hz, 1H), 2.03 (s, 3H), 2.01 (s, 3H), 1.16 (d, J=6.6 Hz, 3H); ESIMS m/z 398 ([M+H]+).

Workup

  1. extractionthe mixture was extracted with dichloromethane
  2. concentrationThe combined organic phases were concentrated
  3. customchromatographed (0-100% ethyl acetate/hexanes)

Sources & evidence

ORD record
ord-b4ee168f77e74c56829a2ba8c8506f3b
Source dataset
uspto-grants-2016_08
Patent number
US09422278B2

Reaction notes

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