Trifluoroacetic acid → HCID 86718556, compound

HRID 1485032Notes

Reaction equation

HRID 1485032 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:16]3[N:17]([C:37]([CH3:40])=[N:38][N:39]=3)[N:18]=[C:19]([C:21]3[N:22]([CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[C:23]4[C:28]([CH:29]=3)=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:30]([N:22]1[C:23]2[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:29]=[C:21]1[C:19]1[CH:20]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:16]2[N:17]([C:37]([CH3:40])=[N:38][N:39]=2)[N:18]=1)[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86718554HCID 86718554, compound

Product 1

HCID 86718556HCID 86718556, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[6-(1-Benzyl-1H-indol-2-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (13 mg; 0.02 mmol) was dissolved in 1 ml DCM and treated with 300 μl TFA. It was stirred for 1 hour. The solvent was evaporated and the residue taken up in DCM and extracted with aqueous NaHCO3. The organic layer was dried and evaporated to dryness.

Workup

  1. customThe solvent was evaporated
  2. extractionextracted with aqueous NaHCO3
  3. customThe organic layer was dried
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-14bd714bf6e24f68be891d787da91f36
Source dataset
uspto-grants-2016_08
Patent number
US09422290B2

Reaction notes

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