Tetrahydro-4H-pyran-4-one → Methyl DL-2-(1-Boc-piperidin-4-yl)-beta-glycinate

HRID 1485040Notes

Reaction equation

HRID 1485040 reaction equation
O1CCC(=O)CC1.[C:8]([O:12][C:13]([N:15]1CCC(=O)CC1)=[O:14])([CH3:11])([CH3:10])[CH3:9].[NH2:22][C:23]1([CH2:29][C:30]([O:32][CH3:33])=[O:31])[CH2:28][CH2:27]O[CH2:25][CH2:24]1>>[NH2:22][C:23]1([CH2:29][C:30]([O:32][CH3:33])=[O:31])[CH2:28][CH2:27][N:15]([C:13]([O:12][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:14])[CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 25418820Methyl 4-aminotetrahydro-2H-pyran-4-acetate

Product 1

HCID 25418816Methyl DL-2-(1-Boc-piperidin-4-yl)-beta-glycinate

Procedure

Instead of tetrahydro-4H-pyran-4-one, 1-(tert-butoxycarbonyl)-4-piperidone (5.00 g) was used and treated by the same techniques as in Reference Example 1-1(1) and (2) to give the titled compound as a colorless solid (4.65 g).

Sources & evidence

ORD record
ord-ea8d12b67da74676ad9d6522619276da
Source dataset
uspto-grants-2016_08
Patent number
US09422240B2

Reaction notes

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