Hydrochloric Acid → HCID 67073212, compound

To a solution of crude G or G′ (1 eq.) in anhydrous DCM were added at 0° C. H (1.3 eq.), followed by N-methylmorpholine (2.2 eq.) dropwise over 15 sec. The reaction mixture was stirred at rt for 10 minutes and, the milky suspension was poured into 1 M HCl. The aqueous phase was extracted with DCM. The organic phases were combined, washed with 1 M NaOH, brine, dried over MgSO4 and evaporated to dryness. The crude compound was purified by silica gel chromatography to afford the desired product (R)-I.

1. extractionThe aqueous phase was extracted with DCM
2. washwashed with 1 M NaOH, brine
3. dry with materialdried over MgSO4
4. customevaporated to dryness
5. customThe crude compound was purified by silica gel chromatography

ORD record

ord-5ccbc00c836947128cd22da9b795031a

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09422299B2