Hydrochloric Acid → 3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

HRID 1485510Notes

Reaction equation

HRID 1485510 reaction equation
[NH2:1][C:2]1[C:3]2[S:25][CH:24]=[C:23]([C:26]3[CH:27]=[C:28]([CH:33]=[CH:34][CH:35]=3)[C:29]([NH:31][CH3:32])=[O:30])[C:4]=2[N:5]=[C:6]([NH:8][C:9]2[CH:10]=[N:11][C:12]([N:15]3[CH2:20][CH2:19][N:18]([CH2:21][CH3:22])[CH2:17][CH2:16]3)=[CH:13][CH:14]=2)[N:7]=1.[ClH:36]>O1CCCC1.O1CCOCC1>[ClH:36].[NH2:1][C:2]1[C:3]2[S:25][CH:24]=[C:23]([C:26]3[CH:27]=[C:28]([CH:33]=[CH:34][CH:35]=3)[C:29]([NH:31][CH3:32])=[O:30])[C:4]=2[N:5]=[C:6]([NH:8][C:9]2[CH:10]=[N:11][C:12]([N:15]3[CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH2:20]3)=[CH:13][CH:14]=2)[N:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 532374933-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide

Product 1

HCID 532395413-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

3-(4-Amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide (300 mg, 0.615 mmol) was dissolved in tetrahydrofuran (5 mL) and then 4 M hydrogen chloride (169 μL) dissolved in dioxane was added at room temperature. 5 hours later, thus prepared precipitate was filtered and dried at room temperature. The target compound 3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride (295 mg) was yielded.

Workup

  1. additionwas added at room temperature
  2. filtration5 hours later, thus prepared precipitate was filtered
  3. customdried at room temperature

Sources & evidence

ORD record
ord-59bf86c5950e4ee1920c057253892c1e
Source dataset
uspto-grants-2016_08
Patent number
US09422307B2

Reaction notes

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