反应详情

3-(4-Amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide (300 mg, 0.615 mmol) was dissolved in tetrahydrofuran (5 mL) and then 4 M hydrogen chloride (169 μL) dissolved in dioxane was added at room temperature. 5 hours later, thus prepared precipitate was filtered and dried at room temperature. The target compound 3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride (295 mg) was yielded.

1. additionwas added at room temperature
2. filtration5 hours later, thus prepared precipitate was filtered
3. customdried at room temperature