反应详情

3-Fluoro-4-methoxy-benzaldehyde (10 g) was dissolved in 100 mL of nitromethane along with 5 g of ammonium acetate. The mixture was refluxed for 2 hours. The nitromethane was removed by rotary evaporation and the residue recrystallized from ethanol to give 7.6 g of the expected product. LC-MS showed the product had the expected M+H+ of 198.

1. temperatureThe mixture was refluxed for 2 hours
2. customThe nitromethane was removed by rotary evaporation
3. customthe residue recrystallized from ethanol