Hydrochloric Acid → HCID 117858463, compound

HRID 1486274Notes

Reaction equation

HRID 1486274 reaction equation
C1(C(=[N:14][C:15]([CH3:22])([CH2:18][CH:19]([F:21])[F:20])[C:16]#[N:17])C2C=CC=CC=2)C=CC=CC=1.[ClH:23]>O1CCCC1.O>[ClH:23].[NH2:14][C:15]([CH3:22])([CH2:18][CH:19]([F:21])[F:20])[C:16]#[N:17]

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 90251302HCID 90251302, compound

Product 1

HCID 117858463HCID 117858463, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

10.84 g (33.43 mmol; 92% purity) of rac-2-[(diphenylmethylene)amino]-4,4-difluoro-2-methylbutanonitrile from Example 70A were dissolved in 156 ml of tetrahydrofuran and 6 ml of water, 73.5 ml (36.77 mmol) of hydrogen chloride solution (0.5 N in diethyl ether) were added and the mixture was stirred at room temperature overnight. The reaction solution was admixed with 16.71 ml (33.43 mmol) of hydrogen chloride solution (2 N in diethyl ether) and concentrated by rotary evaporation. The isolated crude product was reacted further directly without further purification.

Workup

  1. concentrationconcentrated by rotary evaporation
  2. customThe isolated crude product
  3. customwas reacted further directly without further purification

Sources & evidence

ORD record
ord-4a23c9daf41047cebedd5e3c10f583d4
Source dataset
uspto-grants-2016_08
Patent number
US09422285B2

Reaction notes

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